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Mcnerney, Megan

One or more keywords matched the following properties of Mcnerney, Megan

Property	Value
keywords	Myeloid Leukemia

One or more keywords matched the following items that are connected to Mcnerney, Megan

Item Type	Name
Concept	Chromosomes, Human, Pair 5
Concept	Chromosomes, Human, Pair 7
Concept	Leukemia, Erythroblastic, Acute
Concept	Herpesvirus 4, Human
Concept	Mice, Transgenic
Concept	Mice, Inbred BALB C
Concept	Mice, Inbred C57BL
Concept	Mice, Nude
Concept	Humans
Concept	Leukemia, Myeloid
Concept	Leukemia, Myeloid, Acute
Concept	Mice, Knockout
Concept	Mice
Concept	Genome, Human
Concept	Disease Models, Animal
Concept	Mice, Mutant Strains
Concept	Mice, SCID
Concept	Mice, Inbred NOD
Academic Article	Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions.
Academic Article	2B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice.
Academic Article	A new self: MHC-class-I-independent natural-killer-cell self-tolerance.
Academic Article	Role of natural killer cell subsets in cardiac allograft rejection.
Academic Article	2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+ T cells.
Academic Article	An integrated genomic approach to the assessment and treatment of acute myeloid leukemia.
Academic Article	Development of warm auto- and allo-antibodies in a 3-year old boy with sickle cell haemoglobinopathy following his first transfusion of a single unit of red blood cells.
Academic Article	Regulatory defects in Cbl and mitogen-activated protein kinase (extracellular signal-related kinase) pathways cause persistent hyperexpression of CD40 ligand in human lupus T cells.
Academic Article	2B4 acts as a non-major histocompatibility complex binding inhibitory receptor on mouse natural killer cells.
Academic Article	Targeted disruption of the 2B4 gene in mice reveals an in vivo role of 2B4 (CD244) in the rejection of B16 melanoma cells.
Academic Article	The CD2 family of natural killer cell receptors.
Academic Article	CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia.
Academic Article	Oral cavity tumors in younger patients show a poor prognosis and do not contain viral RNA.
Academic Article	Bionimbus: a cloud for managing, analyzing and sharing large genomics datasets.
Academic Article	Nfkb1 is a haploinsufficient DNA damage-specific tumor suppressor.
Academic Article	The spectrum of somatic mutations in high-risk acute myeloid leukaemia with -7/del(7q).
Academic Article	Widespread genetic epistasis among cancer genes.
Academic Article	Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation.
Academic Article	Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.
Academic Article	Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.
Academic Article	Clinical Validation of a Next-Generation Sequencing Genomic Oncology Panel via Cross-Platform Benchmarking against Established Amplicon Sequencing Assays.
Academic Article	Robust stratification of breast cancer subtypes using differential patterns of transcript isoform expression.
Academic Article	The haploinsufficient tumor suppressor, CUX1, acts as an analog transcriptional regulator that controls target genes through distal enhancers that loop to target promoters.
Award or Honor Receipt	Leukemia and Lymphoma Society, Illinois Chapter Researcher of the Year
Award or Honor Receipt	Leukemia and Lymphoma Society Fellow Award
Academic Article	Therapy-related myeloid neoplasms: when genetics and environment collide.
Academic Article	System for Informatics in the Molecular Pathology Laboratory: An Open-Source End-to-End Solution for Next-Generation Sequencing Clinical Data Management.
Academic Article	Gene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS.
Academic Article	The Harmful Consequences of Increased Fitness in Hematopoietic Stem Cells.
Academic Article	A phase 1 study of azacitidine with high-dose cytarabine and mitoxantrone in high-risk acute myeloid leukemia.
Academic Article	Cytotoxic Therapy-Induced Effects on Both Hematopoietic and Marrow Stromal Cells Promotes Therapy-Related Myeloid Neoplasms.
Academic Article	Loss of a 7q gene, CUX1, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms.
Academic Article	Venetoclax imparts distinct cell death sensitivity and adaptivity patterns in T cells.
Academic Article	Genomic studies controvert the existence of the CUX1 p75 isoform.
Academic Article	CRISPR screening in human hematopoietic stem and progenitor cells reveals an enrichment for tumor suppressor genes within chromosome 7 commonly deleted regions.
Academic Article	The significance of CUX1 and chromosome 7 in myeloid malignancies.
Award or Honor Receipt	Leukemia and Lymphoma Society Scholar Award
Academic Article	Inherited cancer predisposing mutations in patients with therapy-related myeloid neoplasms.
Academic Article	EGR1 Haploinsufficiency Confers a Fitness Advantage to Hematopoietic Stem Cells Following Chemotherapy.
Academic Article	Oncogenic RAS promotes leukemic transformation of CUX1-deficient cells.
Grant	Next-Generation Sequencing of Therapy-Related Acute Myeloid Leukemia
Grant	The pathogenesis of chromosome 7q deletions in juvenile myelomonocytic leukemia
Grant	Determining the role of CUX1 in myeloid neoplasia
Academic Article	Haploinsufficient Transcription Factors in Myeloid Neoplasms.

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human
leukemias